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Current and Future Treatment of Metabolic Syndrome and Type 2 Diabetes in Children and Adolescents

In Brief The metabolic syndrome and type 2 diabetes are occurring at alarming rates in children. Obesity plays an important role in the increased prevalence of its comorbid conditions including dyslipidemia, hypertension, and type 2 diabetes. Lifestyle modification is the mainstay of prevention and treatment for metabolic syndrome and type 2 diabetes; however, it can be costly and labor-intensive. Pharmacotherapy is considered a second line of therapy in adults, but its use in children is controversial. This article reviews current and potential future drugs for the treatment of obesity, dyslipidemia, hypertension, and type 2 diabetes in children. Surgical procedures for treating severely obese adolescents are also discussed.

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