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Hypothesis 2. Depression increases the risk for coronary heart disease in established diabetes.

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	Foundation Article

 
Clouse RE, Lustman PJ, Freedland KE, Griffith LS, McGill JB, Carney RM: Depression and coronary heart disease in women with diabetes. Psychosom Med 65:376–383, 2003

	Summary and Commentary

 
Prospective population-based studies demonstrate that, among individuals without known coronary heart disease (CHD), those who are depressed are more likely to have a myocardial infarction (MI) or die from cardiovascular disease than those without depression.¹² Clouse et al. hypothesized that depression plays a similar role in the clinical presentation of CHD in individuals with diabetes. Women were selected as the focus of their study because of the high prevalence and aggressive course of CHD in women with diabetes.

The study involved 76 women who composed the female subset of participants recruited and interviewed in 1982 for a study of the interrelationship of diabetes and psychiatric illness. The mean age of the subjects was 41.3 years, with a mean duration of diabetes of 12.4 years. Both type 1 (44.7%) and type 2 (55.3%) diabetic patients were enrolled. The majority . . . [Full Text of this Article]

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