© American Diabetes Association ®, Inc., 2003 Psychological Functioning of Obese Individuals
In Brief This review found that obese individuals in the general population have essentially normal psychological functioning. Obese women, however, are at greater risk than obese men of depression and related complications. Binge eating and extreme obesity further increase the likelihood of patients reporting emotional complications. Pharmacotherapy and psychotherapy may be of benefit in this subset of individuals.
Adults with type 2 diabetes are 50250% more likely than those without diabetes to suffer from depression.1 Depression may be attributable to hyperglycemia,2 diabetes-related health complications,3 or more broadly, the stress of living with a chronic health condition. Obesity, another chronic condition, commonly co-occurs with type 2 diabetes. Nearly half of all people with type 2 diabetes are obese (i.e., have a BMI 30 kg/m2), and two-thirds have a BMI of at least 27 kg/m2.4 This article reviews the psychosocial correlates of obesity with special emphasis on mood disturbance. We begin by examining two factorsprejudice and discriminationthat would appear likely to contribute to depression and other adverse emotions in obese individuals. We then review the prevalence of mood disturbances among obese individuals, with particular attention to risk factorsincluding sex, presence of binge eating, and degree of obesitythat may increase the likelihood that a patient will present with clinically significant psychopathology. We examine the impact of obesity on body image and quality of life, as well as the effects of weight loss and weight regain (i.e., weight cycling) on mood. We conclude with recommendations for the treatment of psychosocial complications in obese individuals.
The prevalence of obesity in the United States has grown from 15% in 1980 to 30% in 2000.5 Other developed nations have also seen dramatic increases in the rates of this disorder, which has prompted the World Health Organization to label obesity a global epidemic.6 Despite worldwide increases in obesity and the recognition of genetic contributions to weight, negative attitudes and behaviors toward obese individuals persist in American society and are likely exacerbated by our cultures idealization of thinness. Some assert that ridicule and disparagement of obese individuals remain the last socially acceptable form of prejudice.7 Prejudice against obese individuals begins early in life. A classic study by Staffieri8 demonstrated anti-fat attitudes in children 6 years old, who characterized silhouettes of an overweight child as "lazy," "dirty," "stupid," and "ugly." Children in Staffieris study also indicated that the figure "lies and cheats." More recently, Cramer and Steinwert9 found evidence for the "fat is bad" stereotype among boys and girls as young as 3 years old. Children in their study rated a chubby target figure significantly more negatively than otherwise equivalent thin or average-weight figures. Obesity-related stigma persists through adolescence and adulthood. College students, for instance, rated obese individuals as less suitable marriage partners than embezzlers, cocaine users, and shoplifters.10 Health care professionals also have been found to hold negative attitudes toward obese individuals. In one study,11 physicians associated poor hygiene, noncompliance, hostility, and dishonesty with obese patients. In another study,12 nurses indicated that obese individuals harbor unresolved anger and are lazier, more overindulgent, and less successful than individuals of average weight. Teachman and Brownell13 found that health care professionals who represented a variety of disciplines but specialized in obesity treatment demonstrated little explicit anti-fat bias. However, they clearly showed implicit negative attitudes toward the obese, although at lower levels than in the general population. Normal-weight individuals might be expected to hold stronger anti-fat attitudes than obese people.14 In Cramer and Steinwerts study, however, overweight children demonstrated stronger "fat is bad" attitudes than did children of average weight.9 Among adults, negative attitudes toward obesity appear to be unrelated to weight.15 The nonsignificant relationship between BMI and anti-fat attitudes suggests that obese people themselves may associate obesity with unfavorable characteristics. Anti-fat attitudes can even transfer to people who are not overweight. Hebl and Mannix16 examined individuals evaluations of an average-weight male job applicant who was seen in the company of either an obese or an average-weight woman. Those who saw the applicant seated next to the obese woman rated him less favorably than those who saw him with the average-weight woman. This stigma-by-association effect was observed whether the rater was male or female, whether the rater thought the obese woman was a romantic partner of the applicant or a stranger, and whether the observer held explicit anti-fat attitudes. The natural consequence of negative attitudes toward obese individuals is discriminatory behavior. The findings of Hebl and Mannix16 illustrate the potential for obese people (and their associates) to be evaluated unfairly in employment settings. Indeed, several studies have found discriminatory treatment of obese peopleespecially obese women17in virtually all stages of employment, including selection, placement, compensation, promotion, discipline, and discharge.18,19 Discrimination is similarly apparent in the realm of educational attainment. Crandall,20,21 for example, found that overweight children received less financial support from their parents to pay for college than did their average-weight peers, even when controlling for parental income, ethnicity, family size, and childrens grades. As is true in employment settings, weight-related discrimination in educational settings is experienced more strongly by women than by men. Roehling,19 as well as Puhl and Brownell,22 have provided thorough reviews of discrimination toward obese individuals. Prejudice and discrimination can be conceptualized as chronic stressors that could have deleterious effects on emotional well-being. Given societys bias against them, obese individuals might be expected to experience more psychological distress than their average-weight peers. The following section reviews the prevalence of psychopathology among obese people and the associations between BMI and psychological distress.
Obese individuals are frequently thought to suffer from depression, low self-esteem, and related problems. Anecdotal and theoretical accounts of the psychological causes and effects of obesity abound. According to traditional psychoanalytic thought, overeating (and subsequent obesity) is the product of a deep sense of dependency that arises in the oral stage of development when the infants basic needs are not adequately satisfied.23 Obese people themselves may attribute their weight to a tendency to view food as a source of comforta friend who can help them copein times of stress, anger, depression, and loneliness. One may look at extremely obese individuals and assume that they cannot be happy or must have low self-esteem as a result of their weight.
Studies of the general population The lack of consistency and clinical significance found in population-based studies led some researchers to conclude that there were essentially no differences in the psychological functioning of obese and nonobese people.26 A later generation of researchers,27 however, argued that better-designed studies were needed including: 1) large, nationally representative samples, as opposed to small samples of convenience; 2) consistent criteria to define overweight and obesity; 3) assessment tools that yield clinical diagnoses, as opposed to paper-and-pencil inventories; and 4) appropriate control groups.
At least two studies28,29 have met these requirements. Istvan et al.28 examined the relationship between BMI and depression, as measured by the Center for Epidemiologic Studies Depression (CES-D) scale,30 in a nationally representative sample of 32,000 adults aged 2574 years. They found no relationship between BMI and CES-D scores among men. Women in the highest quintile of BMI (BMI
Carpenter et al.29 similarly studied a large, nationally representative sample (of more than 40,000 people) and found that the relationship between obesity and depression varied by sex. Using a structured interview, the investigators found that obese men (those with a BMI
Studies of clinical populations In their meta-analytic review, Friedman and Brownell27 concluded that obesity was moderately (average effect size = 0.52) and consistently related to depression in studies that compared obese individuals who sought treatment with people in the general population. Obese patients who sought weight reduction reported significantly greater psychological distress than did comparably obese individuals who did not seek treatment.36 By contrast, obese individuals who did not seek weight loss did not differ from average-weight individuals with respect to psychopathology.36 Treatment-seeking status, therefore, is an important factor to consider when examining the relationship between obesity and psychopathology.27,37 Appropriate comparison groups for obese treatment-seekers could include samples of average-weight and obese individuals who sought general medical or surgical procedures.
The studies reviewed thus far have attempted to answer whether obesity is related to increased psychopathology. As Wadden and Stunkard26 concluded in 1985, the answer to this broad question appears to be "no." Research into relationships between obesity and psychosocial outcomes has now entered a second generation.27 The focus of inquiry has shifted from whether obesity is related to greater psychological distress to which obese people are at increased risk for psychopathology. This approach recognizes the heterogeneity among obese individuals. Given the prevalence of overweight and obesity, there may be greater variability among these individuals than there is between obese and nonobese people. In the following section, we review the characteristics that may be associated with increased risk of psychopathology (particularly depression) among obese individuals.
Sex Women are under greater societal pressure than men to be thin. Females are teased about their weight more than men and report higher levels of body image dissatisfaction.38 Thus, it is not surprising that weight has more negative psychosocial effects in women than in men. The findings of Carpenter et al.29 and Istvan et al.28 are remarkably similar. Obese women in the general population were 37 and 38% more likely, respectively, to be depressed as compared to their average-weight peers. For men in these studies, obesity was either unrelated to mood28 or was associated with significantly fewer symptoms of depression.29 The finding that the relationship between weight and depression is different for men and women must be considered when examining the broad psychosocial correlates of obesity. Studies that estimate the prevalence of psychopathology among obese treatment-seekers, in particular, must be interpreted with caution. As is true with psychotherapy in general,39 women are more likely than men to seek weight loss therapy. Because females represent as much as 80% of treatment-seekers40 they are likely to be over-represented in obesity research. Furthermore, the types of psychopathology that are typically assessed in obesity research (i.e., depression, anxiety, eating disorders, and borderline personality disorder) are more common among women than men, regardless of weight.41 Given the sex distribution and types of distress examined in clinical obesity studies, the association between weight and pathology may appear stronger than it is.
Binge eating As many as 30% of obese individuals who seek weight loss treatment appear to meet criteria for BED, based on self-report.42 When diagnosed by a clinical interview, however, the rates fall to 7.618.8%.43 The prevalence of BED in obese treatment-seekers, while decidedly higher than in the general population, illustrates that most obese individuals do not routinely consume large quantities of food and lose control over their eating. Binge eating is also encountered in overweight patients with type 2 diabetes. Crow et al.44 assessed 43 consecutive patients in a diabetes clinic and found that one-fourth met criteria for BED. Other studies45,46 found lower rates of binge eating (621%) among patients with type 2 diabetes. Patients in the Crow study44 who were diagnosed with BED had a significantly higher BMI than their nonbingeing counterparts. Glycosolated hemoglobin, however, did not differ between bingeing and nonbingeing patients. Binge eating and psychopathology. Two of three studies4749 found significantly more depressive symptoms in obese patients with BED, as determined by interview, than in obese nonbingers. Numerous other studies found that binge eaters, compared with nonbinge eaters, reported not only more symptoms of depression, but also lower self-esteem, greater symptoms of borderline personality disorder, and greater lifetime prevalence of any Axis I mental disorder, including substance abuse or dependence.48,5056 The presence of binge eating, therefore, can be considered a risk factor for depression and various other forms of psychopathology.
Extreme obesity
Extreme obesity and psycho-pathology. Some27,37 have suggested that the risk of psychological distress also may increase with greater severity of obesity. Wadden et al.37 found that obese patients with a BMI
While some obese individuals experience depression and related complications, most obese people appear to have essentially normal psychological functioning. These individuals, however, may have physical or psychosocial complications of their excess weight that detract from their well-being, even if their problems do not rise to the level of a psychiatric diagnosis. In this section, we discuss the relationship between obesity and subclinical syndromes, such as impaired quality of life or body image.
Health-related quality of life Physical pain may have a major impact on HRQL in obese individuals. Osteoarthritis, knee pain, and back pain, in particular, are common among obese individuals and are positively associated with BMI.63 The presence of pain may account for much of the variance in the relationships between BMI and other aspects of HRQL.64,65 The experience of pain could mediate the relationship between BMI and psychological distress (e.g., depression) in extremely obese individuals, although this hypothesis has not been tested.
Body image dissatisfaction The severity of body image dissatisfaction is significantly greater among obese treatment-seekers than among nonobese individuals. Sarwer et al.72 found that 68% of obese individuals who sought weight reduction (BMI = 35.6 ± 4.3 kg/m2) and 33% of nonobese controls (BMI = 23.8 ± 3.2 kg/m2) reported moderate to extreme dissatisfaction with their overall appearance. The waist/abdomen was the most dissatisfying feature for both the obese patients (47%) and controls (42%). A greater percentage of obese individuals (72%) were moderately to extremely dissatisfied with their most dissatisfying feature than were controls (49%). The earlier people become obese, the more likely they are to be dissatisfied with their bodies.73 Several studies have observed a relationship between being teased about weight in childhood and body image dissatisfaction in adulthood.74,75 Others,34 however, found that adulthood teasing was more strongly related to body image dissatisfaction than was childhood teasing. The relationship between recalled childhood teasing and body image may be partly explained by biases in memory due to current mood and self-esteem.34 Binge eating also appears to be associated with body image dissatisfaction. Obese bingers reported significantly greater dissatisfaction than did obese nonbingers; the increased dissatisfaction among bingers could not be explained by mood or BMI.51 Although obese people are more dissatisfied with their bodies than are their average-weight peers, body image dissatisfaction is moderately to strongly associated with greater depressive symptoms and lower self-esteem regardless of weight.69 The direction of the relationship between body image dissatisfaction and clinically significant depression is unknown. Research has yet to determine whether depressed individuals evaluate their bodies more negatively than do nondepressed people, whether dissatisfaction with appearance increases vulnerability to depression, or whether one or more other factors simultaneously increase the risk of both depression and body image dissatisfaction.
Dieting has become Americas new national pastime. At any given moment, 45% of women and 30% of men are trying to lose weight.76 Weight loss, as well as weight regain, may be associated with emotional consequences, both positive and negative. Intentional weight loss is associated with improvements in mood,77 quality of life,78 and body image.79 These benefits appear to result whether the weight was lost with diet and exercise,80 very-low-calorie diets,81 pharmacotherapy,82 or bariatric surgery.83
Weight cycling Contrary to expectations, however, weight loss and regain (i.e., weight cycling) does not appear to be associated with clinically significant depression. Cross-sectional studies that found no differences in depression between individuals with and without a history of weight cycling8789 have been criticized for methodological limitations. More rigorous longitudinal studies, however, have yielded similar conclusions.85,90,91 For example, Foster et al.91 found that obese women who lost an average of 21.1 kg after 6 months of treatment but were 3.6 kg above baseline 5 years post-treatment exhibited significant improvements in mood. Mean scores on the Beck Depression Inventory (BDI)92 dropped from 12.7 to 9.3 at follow-up. These women also reported significant reductions in hunger and disinhibition of eating. While studies suggest that weight cycling does not result in clinically significant depression, it is associated with decreased satisfaction with appearance, self-esteem, and self-confidence.93 The generally favorable finding that weight cycling is unrelated to depression should not lead clinicians to minimize the shame and distressif subclinical in severitythat patients frequently report in response to a history of failed attempts to control their weight.
Obese patients and their health care providers may readily conclude that any distress patients experience is attributable to their size and that they "just need to lose weight." Clinicians are cautioned, however, against assuming that obese people who suffer from significant depression are depressed because they are obese. The vast majority of obese people, in fact, are not depressed. Those who do have a mood disorder deserve and require the same care that would be provided to a depressed person of average weight. We recommend that patients with major depression be treated for their mood disturbance before weight loss is undertaken. The cognitive and behavioral symptoms of depression (e.g., poor concentration, low motivation, social withdrawal) can diminish patients capacity to adhere to a weight loss program, leaving them vulnerable to attrition, unsatisfactory weight loss, and exacerbation of the mood disorder.
Treatment of depression Some psychotherapies have been found to be as effective as pharmacotherapy for treating depression.97 Cognitive-behavioral therapy and interpersonal psychotherapy are among the most common psychological interventions for depression and have received strong empirical support.98 Persons et al.99 have reviewed the role of psychotherapy in the treatment of depression.
Treatment of binge eating One study101 suggests that the well-known antidepressant fluoxetine may be efficacious for treating BED as well as depression. Patients were randomly assigned to receive placebo or a flexible dose of fluoxetine (mean = 71.3 ± 11.4 mg/day) for 6 weeks. As compared to placebo controls, patients who received fluoxetine had significantly greater reductions in binge frequency and BMI, as well as a greater reduction in depressive symptoms that approached significance (P = 0.06). The nature of the relationship between binge eating and depression is not fully understood. Studies have yet to illuminate whether binge eating is secondary to depression, whether the converse is true, or whether a more complex relationship exists between the two disorders. More research is necessary to clarify these issues.
Life stress The assessment of stressors is particularly important in evaluating patients candidacy for bariatric surgery. Surgery is best postponed for individuals experiencing acute stressors that are expected to resolve in a specific amount of time (e.g., a move, an impending divorce, a childs wedding). We recommend that surgery be delayed until more energy is available to devote to the task of postoperative recovery and behavior change. Adjunctive support to bolster patients emotional resources is recommended for those under chronic stress with no foreseeable resolution (e.g., poverty, marital distress, disease).
This review has not supported the common assumption that obesity is broadly associated with depression and other psychopathology. In men in particular, excess weight may be associated with a reduced risk of psychological complications. Conversely, being female, binge eating, and having a BMI 40 kg/m2 increase the likelihood that a patient will report a significant mood disturbance. People who seek professional weight loss therapy also are more likely to be depressed than nontreatment-seeking obese individuals. Their mood disturbance may be one of the factors that prompts them to seek weight loss. Depression in obese people should not be assumed to be attributable solely to weight. Although losing weight does improve mood, clinicians should not expect patients depression to remit with weight loss. Treatment of the mood disorder with psychotherapy or pharmacotherapy should precede weight loss therapy. Alleviation of patients psychological distress should improve their ability to adhere to diet and activity recommendations and, thus, achieve the weight loss they seek.
Preparation of this article was supported in part by grant 1-U01-DK57135 from the National Institute of Diabetes and Digestive and Kidney Diseases.
Anthony N. Fabricatore, PhD, is an instructor of psychology, and Thomas A. Wadden, PhD, is a professor of psychology and director of the Weight and Eating Disorders Program in the Department of Psychiatry at the University of Pennsylvania School of Medicine in Philadelphia.
2 Lustman PJ, Anderson RJ, Freedland KE, de Groot M, Carney RM, Clouse RE: Depression and poor glycemic control: a meta-analytic review of the literature. Diabetes Care 23:934942, 2000[Abstract] 3 de Groot M, Anderson RJ, Freedland KE, Clouse RE, Lustman PJ: Association of diabetes complications and depression in type 1 and type 2 diabetes: a meta-analysis [Abstract]. Diabetes 49 (Suppl. 1):A63, 2000
4 National Task Force on the Prevention and Treatment of Obesity: Dieting and the development of eating disorders in overweight and obese adults. Arch Intern Med 160:25812589, 2000
5 Flegal KM, Carroll MD, Ogden CL, Johnson CL: Prevalence and trends in obesity among US adults. JAMA 288:17231727, 2002 6 World Health Organization: Obesity: Preventing and Managing the Global Epidemic. Geneva, World Health Organization, 1998 7 Sobal J, Stunkard AJ: Socioeconomic status and obesity: a review of the literature. Psychol Bull 105:260275, 1989[Medline] 8 Staffieri JR: A study of social stereotype of body image in children. J Pers Soc Psychol 7:101104, 1967[Medline] 9 Cramer P, Steinwert T: Thin is good, fat is bad: how early does it begin? J Appl Devel Psychol 19:429451, 1998 10 Vener AM, Krupka LR, Gerard RJ: Overweight/obese patients: an overview. Practitioner 226:11021109, 1982[Medline] 11 Klein D, Najman J, Kohrman AF, Munro C: Patient characteristics that elicit negative responses from family physicians. J Fam Pract 14:881888, 1982[Medline] 12 Maroney D, Golub S: Nurses attitudes toward obese persons and certain ethnic groups. Percept Mot Skills 75:387391, 1992[Medline] 13 Teachman BA, Brownell KD: Implicit anti-fat bias among health professionals: is anyone immune? Int J Obes Relat Metab Disord 25:15251531, 2001[Medline] 14 Tajfel H: Social Identity and Intergroup Relations. Cambridge, Cambridge University Press, 1982 15 Crandall CS: Prejudice against fat people: ideology and self-interest. J Pers Soc Psych 66:882894, 1994 16 Hebl MR, Mannix LM: The weight of obesity in evaluating others: a mere proximity effect. Pers Soc Psychol Bull 29:28-38, 2003[Abstract] 17 Pingitore R, Dugoni R, Tindale S, Spring B: Bias against overweight job applicants in a simulated employment interview. J Appl Psychol 79:909917, 1994[Medline] 18 Frieze IH, Olson JE, Good DC: Perceived and actual discrimination in the salaries of male and female managers. J Appl Soc Psychol 20:4667, 1990 19 Roehling MV: Weight-based discrimination in employment: psychological and legal aspects. Personnel Psychology 52:9691016, 1999 20 Crandall CS: Do heavy-weight students have more difficulty paying for college? Pers Soc Psychol Bull 17:606611, 1991[Abstract] 21 Crandall CS: Do parents discriminate against their heavy-weight daughters? Pers Soc Psychol Bull 21:724735, 1995[Abstract] 22 Puhl R, Brownell KD: Bias, discrimination, and obesity. Obes Res 9:788805, 2001[Medline] 23 Bychowski G: On neurotic obesity. Psychoanal Rev 37:301319, 1950 24 Moore ME, Stunkard AJ, Srole L: Obesity, social class, and mental illness. JAMA 181:962966, 1962
25 Stewart AL, Brook RH: Effects of being overweight. Am J Publ Health 73:171178, 1983 26 Wadden TA, Stunkard AJ: The psychological and social complications of obesity. Ann Intern Med 103:10621067, 1985 27 Friedman MA, Brownell KD: Psychological correlates of obesity: moving to the next research generation. Psychol Bull 117:320, 1995[Medline] 28 Istvan J, Zavela K, Weidner G: Body weight and psychological distress in NHANES I. Int J Obes 16:999003, 1992[Medline]
29 Carpenter KM, Hasin DS, Allison DB, Faith MS: Relationships between obesity and DSM-IV major depressive disorder, suicide ideation, and suicide attempts: rsults from a general population study. Am J Public Health 90:25157, 2000 30 Radloff LS: The CES-D Scale: a self-report depressive scale for research in the general population. J Appl Psychol Meas 1:385401, 1977 31 Gertler R, Ramsey-Stewart G: Pre-operative psychiatric assessment of patients presenting for gastric bariatric surgery (surgical control of morbid obesity). Aust N Z J Surg 56:157161, 1986.[Medline] 32 Goldsmith SJ, Anger-Fiedfeld K, Beren S, Rudolph D, Boeck M, Aronne L: Psychiatric illness in patients presenting for obesity treatment. Int J Eat Dis 12:6371, 1992 33 Halmi KA, Long M, Stunkard AJ, Mason E: Psychiatric diagnosis of morbidly obese gastric bypass patients. Am J Psychiatry 134:470472, 1980 34 Hopkinson LC, Bland RC: Depressive symptoms in grossly obese women. Can J Psychiatry 27:213215, 1982[Medline] 35 Wadden TA, Sarwer DB, Womble LG, Foster GD, McGuckin BG, Schimmel A: Psychosocial aspects of obesity and obesity surgery. Surg Clin North Am 81:10011024, 2001[Medline] 36 Fitzgibbon ML, Stolley MR, Kirschenbaum DS: Obese people who seek treatment have different characteristics than those who do not seek treatment. Health Psychol 12:342345, 1993[Medline] 37 Wadden TA, Womble LG, Stunkard AJ, Anderson DA: Psychosocial consequences of obesity and weight loss. In Handbook of Obesity Treatment. Wadden TA, Stunkard AJ, Eds. New York, Guilford Press, 2002, p. 144169 38 Rodin J: Determinants of body fat and its implications for health. Ann Behav Med 14:275281, 1992 39 Beutler LE: Eclectic Psychotherapy: A Systematic Approach. New York, Pergamon, 1983 40 Wadden TA, Foster GD, Letizia KA, Stunkard AJ: A multicenter evaluation of a proprietary weight reduction program for the treatment of marked obesity. Arch Intern Med 152:961966, 1992[Abstract] 41 Marlowe CM, Schneider SL, Nelson SE: Gender and attractiveness biases in hiring decisions: are more experienced managers less biased. J Appl Psychol 81:1121, 1996 42 Spitzer RL, Devlin M, Walsh TB, Hasin D, Marcus MD, Stunkard AJ, Wadden TA, Yanovski S, Agras WS, Mitchell J, Nonas C: Binge eating disorder: a multisite field trial of the diagnostic criteria. Int J Eat Disord 11:191203, 1992 43 Stunkard AJ: Binge eating and the night eating disorder. In Handbook of Obesity Treatment. Wadden TA, Stunkard AJ, Eds. New York, Guilford Press, 2002, p. 107121 44 Crow S, Kendall D, Praus B, Thuras P: Binge eating and other psychopathology in patients with type II diabetes mellitus. Int J Eat Disord 30:222226, 2001[Medline] 45 Wing RR, Marcus MD, Epstein LH, Blair EH, Burton LR: Binge eating in obese patients with type II diabetes. Int J Eat Disord 8:671679, 1989 46 Kenardy J, Bowen K, Mensch M, Pearson SA: A comparison of eating behaviors in newly diagnosed NIDDM patients and case-matched control subjects. Diabetes Care 17:11971199, 1994[Abstract] 47 Kuehnel RH, Wadden TA: Binge eating disorder, weight cycling, and psychopathology. Int J Eat Disord 15:321329, 1994[Medline] 48 Mussell MP, Mitchell JE, de Zwaan M, Crosby RD, Seim H, Crow SJ: Clinical characteristics associated with binge eating in obese females: a descriptive study. Int J Obes 20:324331, 1996 49 Brody ML, Walsh BT, Devlin M: Binge eating disorder: reliability and validity of a new diagnostic category. J Consult Clin Psychol 62:381386, 1994[Medline] 50 Eldredge KL, Agras WS: Weight and shape overconcern and emotional eating in binge eating disorder. Int J Eat Dis 19:7382, 1996 51 Mussell MP, Peterson CB, Weller CL, Crosby RD, Seim HC, Crow SJ: Differences in body image and depression among obese women with and without binge eating disorder. Obes Res 20:324331, 1996 52 Specker S, de Zwaan M, Raymond N, Mitchell J: Psychopathology in subgroups of obese women with and without binge eating disorder. Comp Psychiatry 35:185190, 1994 53 Tanofsky MB, Wilfley DE, Spurrell EB, Welch R, Brownell KD: Comparison of men and women with binge eating disorder. Int J Eat Dis 21:4954, 1997 54 Telch CF, Agras WS: Obesity, binge eating and psychopathology: are they related? Int J Eat Disord 15:5361, 1994[Medline] 55 Williamson DA, Martin CK: Binge eating disorder: a review of the literature after publication of DSM-IV. Eating Weight Disord 4:103114, 1999[Medline]
56 Yanovski SZ, Nelson JE, Dubbert BK, Spitzer RL: Association of binge eating disorder and psychiatric comorbidity in obese subjects. Am J Psychiatry 150:14721479, 1993
57 Calle EE, Thun MJ, Petrelli JM, Rodriguez C, Heath CW: Body-mass index and mortality in a prospective cohort of U.S. adults. N Engl J Med 341:10971105, 1999 58 Fontaine KR, Barofsky I, Cheskin LJ: Predictors of quality of life for obese persons. J Nervous Mental Disease 185:120122, 1997[Medline] 59 Kolotkin RL, Meter K, Williams GR: Quality of life and obesity. Obesity Revs 2:219229, 2001 60 Fontaine KR, Cheskin LJ, Barofsky I: Health-related quality of life in obese persons seeking treatment. J Fam Pract 43:265270, 1996[Medline] 61 Kolotkin RL, Crosby RD, Williams GR: Health-related quality of life varies among obese subgroups. Obes Res 10:748756, 2002[Medline] 62 Doll HA, Petersen SEK, Stewart-Brown SL: Obesity and physical and emotional well-being: associations between body mass index, chronic illness, and the physical and mental components of the SF-36 questionnaire. Obes Res 8:160170, 2000[Medline] 63 Manek NJ, Hart D, Spector TD, MacGregor AJ: The association of body mass index and osteoarthritis of the knee joint: an examination of genetic and environmental influences. Arth Rheum 48:10241029, 2003[Medline] 64 Heo M, Allison DB, Faith MS, Zhu S, Fontaine KR: Obesity and quality of life: mediating effects of pain and comorbidities. Obes Res 11:209216, 2003[Medline] 65 Barofsky I, Fontaine KR, Cheskin LJ: Pain in the obese: impact on health-related quality-of-life. Ann Behav Med 19:408410, 1997[Medline] 66 Rodin J, Silberstein L, Striegel-Moore R: Women and weight: a normative discontent. Nebraska Symposium on Motivation 32:267307, 1984[Medline] 67 Cash TF, Henry P: Womens body images: the results of a national survey in the U.S.A. Sex Roles 33:1928, 1995 68 Garner DM: The 1997 body image survey results. Psychol Today 31:3087, 1997 69 Sarwer DB, Thompson JK: Obesity and body image disturbance. In Handbook of Obesity Treatment. Wadden TA, Stunkard AJ, Eds. New York, Guilford Press, 2002, p. 447464 70 Matz PE, Foster GD, Faith MS, Wadden TA: Correlates of body image dissatisfaction among overweight women seeking weight loss. J Consult Clin Psychol 70:10401044, 2002[Medline] 71 Thompson JK, Stice E: Thin-ideal internalization: mounting evidence for a new risk factor for body-image disturbance and eating pathology. Curr Dir Psychol Sci 10:181183, 2001 72 Sarwer DB, Wadden TA, Foster GD: Assessment of body image dissatisfaction in obese women: specificity, severity and clinical significance. J Consult Clin Psychol 66:651654, 1998[Medline] 73 Wardle J, Waller J, Fox E: Age of onset and body dissatisfaction in obesity. Addict Behav 27:561573, 2002[Medline] 74 Grilo CM, Wilfley D, Brownell KD, Rodin J: Teasing, body image, and self-esteem in a clinical sample of obese women. Addict Behav 19:443450, 1994[Medline] 75 Thompson JK, Coovert M, Richards KJ, Johnson S, Cattarin J: Development of body image and eating disturbance in young females: covariance structure modeling and longitudinal analyses. Int J Eat Dis 18:221236, 1995
76 Serdula MK, Mokdad AH, Williamson DF, Galuska DA, Mendlein JM, Heath GW: Prevalence of attempting weight loss and strategies for controlling weight. JAMA 282:13531358, 1999 77 Wing RR, Epstein LH, Marcus MD, Kupfer DJ: Mood changes in behavioral weight loss programs. J Psychosom Res 28:345346, 1984[Medline] 78 Fontaine KR, Barofsky I, Anderson RE, Bartlett SJ, Wiersema L, Cheskin LJ, Franckowiak SC: Impact of weight loss on health-related quality of life. Qual Life Res 8:275277, 1999[Medline] 79 Sorbara M, Geliebter A: Body image disturbance in obese outpatients before and after weight loss in relation to race, gender, binge eating, and age of onset. Int J Eat Dis 31:416423, 2002 80 Wadden TA, Vogt RA, Andersen RE, Bartlett SJ, Foster GD, Kuehnel RH, Wilk J, Weinstock R, Buckenmeyer P, Berkowitz RI, Steen SN: Exercise in the treatment of obesity: effects of four interventions on body composition, resting energy expenditure, appetite and mood. J Consult Clin Psychol 65:269277, 1997[Medline] 81 Wadden TA, Foster GD, Letizia KA: One-year behavioral treatment of obesity: Comparison of moderate and severe caloric restrictions and the effects of weight maintenance therapy. J Consult Clin Psychol 62:165171, 1994[Medline] 82 Jain AK, Kaplan RA, Gadde KM, Wadden TA, Allison DB, Brewer ER, Leadbetter RA, Richard N, Haight B, Jamerson BD, Buaron KS, Metz A: Bupropion SR vs. placebo for weight loss in obese patients with depressive symptoms. Obes Res 10:10491056, 2002[Medline] 83 Choban PS, Onyejekwe J, Burge JC, Flancbaum L: A health status assessment of the impact of weight loss following Roux-en-Y gastric bypass for clinically severe obesity. J Am Coll Surg 188:491497, 1999[Medline] 84 Wadden TA, Foster GD: Behavioral treatment of obesity. Med Clin N Amer 84:441461, 2000[Medline] 85 Wadden TA, Sternberg JA, Letizia KA, Stunkard AJ, Foster GD: Treatment of obesity by very-low-calorie diet, behavior therapy and their combination: a five-year perspective. Int J Obes 51:167172, 1989 86 Howard L, Malone M, Michalek A, Carter J, Alger S, Van Woert J: Gastric bypass and vertical banded gastroplasty: a prospective randomized comparison and 5-year follow-up. Obes Surg 5:5560, 1995[Medline] 87 Bartlett SJ, Wadden TA, Vogt RA: Psychosocial consequences of weight cycling. J Consult Clin Psychol 64:587592, 1996[Medline] 88 Foreyt JP, Brunner RL, Goodrick GK, Cutter G, Brownell KD, St. Jeor ST: Psychological correlates of weight fluctuation. Int J Eat Disord 17:263275, 1995[Medline] 89 Venditti EM, Wing RR, Jakicic JM, Butler BA, Marcus MD: Weight cycling, psychological health, and binge eating in obese women. J Consult Clin Psychol 64:400405, 1996[Medline] 90 Brownell KD, Stunkard AJ: Couples training, pharmacotherapy, and behavior therapy in the treatment of obesity. Arch Gen Psychiatry 38:1224-1232, 1981[Abstract] 91 Foster GD, Wadden TA, Kendall PC, Stunkard AJ, Vogt RA: Psychological effects of weight loss and regain: a prospective evaluation. J Consult Clin Psychol 64:752-757, 1996[Medline] 92 Beck AT, Steer RA. Manual for the Beck Depression Inventory. New York, Psychological Corporation, 1987 93 Wadden TA, Stunkard AJ, Liebschutz J: Three year follow-up of the treatment of obesity by very-low-calorie diet, behavior therapy, and their combination. J Consult Clin Psychol 56:925 928, 1988[Medline] 94 Masand PS, Gupta S: Selective serotonin-reuptake inhibitors: an update. Harv Rev Psychiatry 7:69-84, 1999[Medline] 95 Brownell KD, Wadden TA: Obesity. In Comprehensive Textbook of Psychiatry. 7th edit. Sadock BJ, Sadock VA, Eds. Philadelphia, Lippincott, Williams, & Wilkins, 2000, p. 1787 1797 96 Anderson JW, Greenway FL, Fujioka K, Gadde KM, McKenney J, ONeil PM: Buproprion SR enhances weight loss: a 48-week double-blind, placebo-controlled trial. Obes Res 10:633641, 2002[Medline] 97 Antonuccio DO, Danton WG, DeNelsky GY: Psychotherapy versus medication for depression: challenging the conventional wisdom with data. Prof Psychol Res Pract 26:574585, 1995 98 Chambless DL: Training and dissemination of empirically validated psychological treatments: report and recommendations. Clin Psychol Rev 48:323, 1995 99 Persons JB, Thase ME, Crits-Christoph P: The role of psychotherapy in the treatment of depression: review of two practice guidelines. Arch Gen Psychiatry 53:283290, 1996[Abstract] 100 Gladis MM, Wadden TA, Foster GD, Vogt RA, Wingate BJ: A comparison of two approaches to the assessment of binge eating in obesity. Int J Eating Disord 23:1726, 1998[Medline] 101 Arnold LM, McElroy SL, Hudson JI, Welge JA, Bennett AJ, Keck PE: A placebo-controlled, randomized trial of fluoxetine in the treatment of binge-eating disorder. J Clin Psychiatry 63:10281033, 2002[Medline] 102 Wadden TA, Letizia KA: Predictors of attrition and weight loss in persons treated by moderate and severe caloric restriction. In Treatment of the Seriously Obese Patient. Wadden TA, Van Itallie TB, Eds. New York, Guilford Press, 1992, p. 383410 This article has been cited by other articles:
| |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||