The Pathophysiology of Cardiovascular Disease and Diabetes: Beyond Blood Pressure and Lipids

  1. Betsy B. Dokken, PhD, NP, CDE


    In Brief

    The pathophysiology of the link between diabetes and cardiovascular disease (CVD) is complex and multifactorial. Understanding these profound mechanisms of disease can help clinicians identify and treat CVD in patients with diabetes, as well as help patients prevent these potentially devastating complications. This article reviews the biological basis of the link between diabetes and CVD, from defects in the vasculature to the cellular and molecular mechanisms specific to insulin-resistant states and hyperglycemia. It concludes with a discussion of heart failure in diabetes, a clinical entity that demonstrates many of the mechanisms discussed.


    • Betsy B. Dokken, PhD, NP, CDE, is an assistant professor of medicine in the Section of Endocrinology, Diabetes, and Hypertension at the University of Arizona, in Tucson. She is an associate editor of Diabetes Spectrum.

    | Table of Contents

    This Article

    1. doi: 10.2337/diaspect.21.3.160 Diabetes Spectrum vol. 21 no. 3 160-165