Obesity Pharmacotherapy in Patients With Type 2 Diabetes

From Research to Practice

¹Department of Health Policy, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD
²George Washington University School of Medicine, Washington, DC
³Department of Nutrition and Metabolic Research, Scripps Clinic, La Jolla, CA

Diabetes Spectrum 2017 Nov; 30(4): 250-257. https://doi.org/10.2337/ds17-0044

Article Figures & Tables

TABLE 1.

Diabetes Medications That Tend to Increase Weight, Decrease Weight, or Are Weight Neutral

Medications That Contribute to Weight Gain	Medications That Contribute to Weight Loss	Weight-Neutral Medications
• Sulfonylureas (e.g., glipizide, glyburide, and glimepiride)	• GLP-1 receptor agonists (e.g., exenatide and dulaglutide)	• DPP-4 inhibitors (e.g., sitagliptin, saxagliptin, linagliptin, and alogliptin)
• Insulins	• Liraglutide 3.0 mg (a GLP-1 receptor agonist that is also approved for weight loss)	• α-Glucosidase inhibitors (e.g., acarbose and miglitol)
• Thiazolidinediones (e.g., pioglitazone)	• SGLT2 inhibitors (e.g., canagliflozin, dapaglifozin, and empagliflozin)	• Bile acid sequestrants (e.g., colesevelam)
• Meglitinides (e.g., nataglinide and repaglinide)	• Others (e.g., metformin and pramlintide)

TABLE 2.

Common Medications for Weight Loss in Patients With Diabetes

FDA-Approved Medications for Weight Loss	Medications Not Explicitly Approved for Weight Loss
• Liraglutide 3.0 mg	• Metformin
• Naltrexone-bupropion SR	• Pramlintide
• Lorcaserin	• SGLT2 inhibitors
• Phentermine	• SGLT2 inhibitors + phentermine
• Phentermine-topiramate ER
• Orlistat