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From Research to Practice

Pump Therapy for Children: Weighing the Risks and Benefits

View 2: Insulin Pump Therapy in Young Children With Diabetes

  1. Francine Ratner Kaufman, MD,
  2. Mary Halvorson, RN, MNS, CDE,
  3. Sue Carpenter, RN, CDE,
  4. Debra Devoe, MD and
  5. Pisit Pitukcheewanont, MD
    Diabetes Spectrum 2001 Apr; 14(2): 84-89. https://doi.org/10.2337/diaspect.14.2.84
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    View 2: Insulin Pump Therapy in Young Children With Diabetes

    Abstract

    In Brief

    Insulin pump therapy has been shown to be beneficial in pediatric patients with type 1 diabetes; however, there is little data on very young children with regards to the risk/benefit ratio of pump therapy. This article describes the outcomes of insulin pump therapy in young children in our center at Childrens Hospital Los Angeles and the criteria for patient selection.

    Since the introduction of continuous subcutaneous insulin infusion (CSII) in the late 1970s, it has become apparent that the use of insulin pump therapy has many potential benefits for patients with type 1 diabetes.1,2 Because it offers a more physiological way to deliver insulin and, therefore, potentially improves long-term outcome,3 our center began to investigate its use in pediatric patients in the mid-1980s. Once it was shown that pump therapy had benefit in older children and adolescents with regard to improving glycemic control,4,5 reducing hypoglycemia,6 allowing for resumption of normal linear growth,7 and decreasing episodes of recurrent diabetic ketoacidosis (DKA),8 we became increasingly interested in evaluating its use in preschool and early school-aged children with diabetes. This article describes our experience at Childrens Hospital Los Angeles with insulin pump use in young children.

    Patient Selection

    To select pump patients at our center, we have employed standard criteria that span medical, educational, and psychological domains (Table 1). These are essentially the same for all potential pump candidates, including young children whose parents, rather than the child, must meet all of the educational criteria. From a psychological standpoint, all patients, regardless of age, must agree to wear the pump, and they must have tolerated catheter insertion before obtaining the pump to ensure that they understand what this basic component of CSII entails.

    Our center has established four medical indications for CSII (Table 1). These include:

    1.  To optimize basal/bolus insulin therapy. Patients using basal/bolus regimens who desire CSII and want to avail themselves of the latest technology to aid in intensive diabetes management should be considered valid and appropriate pump candidates. This is particularly relevant in young children in whom basal therapy, when done with two injections/day of intermediate-acting insulin, often results in extremes of glycemic excursion due to the unpredictable and unreliable duration of action of this insulin.

    2.  To improve diabetes control. Patients with suboptimal diabetes control despite optimal home management behaviors should be considered for CSII as a means to decrease glycemic excursion and lower HbA1c levels.

    3.  To reduce episodes of severe hypoglycemia. For subjects with recurrent severe hypoglycemia, insulin pump therapy can be used to ameliorate this problem without deteriorating overall diabetes control.

    4.  To reduce episodes of recurrent DKA. By giving a reliable basal infusion rate, CSII can reduce DKA episodes.8

    For success with CSII, patients/families must have the requisite skills and knowledge, as well as the appropriate attitude to learn pump therapy.9,10 The skills and knowledge required beyond learning how to insert, disconnect/suspend, protect, and program the pump include understanding and successfully using carbohydrate management/counting, correcting blood glucose levels outside the target range, sick-day management, and how to adjust for exercise and changes in activity pattern. For young children, all of these must be done by the parent(s) and adult(s) who supervise the young child. As shown in Table 2, our center has developed an eight-stage competency system. The parent(s) of pump candidates must reach the fifth level to be considered capable of managing CSII for their young children.

    Advantages and Disadvantages of CSII in Young Children

    CSII has some potential advantages and disadvantages for young children. For many young patients, it is easier and more convenient to take multiple daily doses of insulin with CSII than with a syringe or insulin pen. Because of erratic eating patterns, subjects can dose after eating and/or use a square wave bolus to better match food absorption and insulin delivery. The pump can deliver doses as small as 0.1 U, and insulin can be diluted conveniently. By using only rapid- or short-acting insulin, one does not have to deal with the unpredictable action and duration of action profiles of intermediate- and long-acting insulins.

    The main disadvantage of pump therapy in young children is that neither the pump nor the child is autonomous. Until CSII is a closed-looped system, pump therapy must only be considered for children who are cared for by a parent or another adult willing and able to learn how to manage all aspects of the pump.

    This is often easier to achieve for preschool rather than primary-school–aged children. Preschool children are home with a parent or in a day care center already committed to successful diabetes management. Most primary schools do not have an on-site school nurse or another adult, such as a teacher or office worker, willing or able to assume the responsibility of caring for a child with an insulin pump.

    Methods for Pump Initiation

    We have modified the six-step pump initiation guidelines so that they are tailored for young children.9,11 These six steps are:

    1.  Determine how much insulin to use in the pump by averaging the total units of insulin used/day for 2 weeks. Decrease by 20% for hypoglycemia, by 10% for euglycemia, and make no reduction for hyperglycemia.

    2.  Divide the total dosage in half—50% for basal and 50% for bolus.

    3.  Divide the portion for basal by 24 to determine the hourly basal rate.

    4.  Check midnight and 3:00 a.m. blood glucose levels for 2 weeks before pump placement for evidence of night or early-morning abnormalities of glycemia. For hypoglycemia, reduce the nighttime basal rate by 10%. For hyperglycemia, increase the 3:00 a.m. by 10%.

    5.  Determine the carbohydrate-to-insulin ratio. (Divide 450 by the total units/day to determine the number of grams of carbohydrate for 1 U insulin.)

    6.  Determine the correction dose for elevated glucose levels. (Divide 1,800 by the total units of insulin/day to determine the mg/dl that 1 U insulin decreases the blood glucose value.)

    Patients/families then monitor glucose levels eight times/day and call for help with management issues daily until the desired glycemic pattern is achieved. On average, patients/families will need to call daily for 2–3 weeks, after which weekly contact is maintained for 3 months. At 3 months, a follow-up HbA1c level is obtained to ensure that pump therapy has maintained or improved glycemic outcome. Once it has been validated that CSII is efficacious, blood glucose monitoring can be done four to six times per day, as is advised in all of our type 1 diabetic patients.

    In our experience, pump therapy does not induce patients/families to display more compulsive behavior than what they had shown previously. For example, the families who choose to routinely monitor more than four to six times/day are those who had done so before CSII. In addition, the relatively low number of basal rates (mean 2.9 ± 2.1/24 h) used by our young children indicates that families do not appear to feel the need to micromanage pump therapy.

    To make pump placement acceptable to our young pediatric subjects, we use local anesthetic cream, such as EMLA (Astra, Westborough, Mass.) to numb the area before catheter insertion. Our catheter of choice for young children is the Silhouette Infusion Set (Maersk Medical, Denmark) This requires hand insertion and enters the abdominal wall at an angle rather than straight. The catheter can then be threaded under the subcutaneous tissue in children who do not have a lot of subcutaneous fat rather than abutting the abdominal fascia, resulting in failure of insulin delivery.

    Pumps with external control devices that can be locked by the parent are also preferable in this age-group. We use a number of belts and pouches to secure placement, including some that have been devised by parents themselves. Overall, the duration the catheter will function in young children is the same as in our older patients (∼3 days). Occasionally, there are patients who are unable to use some, most, or all catheters longer than 2 days; however, we find this in all of our pump patients, regardless of age.

    To facilitate diabetes management with CSII, we have developed a hand-held plastic Insulin Dosage Guide12 that displays how much insulin to give for meals and snacks (carbohydrate counting) and how to correct blood glucose levels outside of the target range. This guide uses an algorithm for increasing the dosage of insulin for every 50 mg/dl that the blood glucose level is above the upper limit of the patient’s target range. The guide has been adjunctive in helping patients in our center achieve a significant reduction in mean HbA1c with CSII (Table 3).

    The guide was originally developed to help patients/families with diabetes management when they first started CSII or other intensive regimens. However, ∼50% of our pump patients/families continue to use it for >3 months after pump placement to be sure that the dosage they are giving is correct.

    We have previously emphasized the importance of having a diabetes team that is familiar with CSII and able to teach pump management to patients/families as the key to success.9,10 These physicians and advanced practice nurses with pump training and certification are the ones in our center who follow patients from start to finish, providing the daily adjustments and ongoing teaching.

    Although some of this could be performed through fax and e-mail, the certified diabetes educators in our center prefer daily phone contact so that an open dialog can be maintained. This obviously requires a significant time commitment, most of which is not reimbursed by third-party payers. Maintaining a pediatric center capable of supporting pump therapy is difficult and can be a financial drain.

    Longitudinal Results of CSII Experience at Childrens Hospital Los Angeles

    Since 1994, we have followed our patients on CSII longitudinally to determine short- and long-term outcomes. We have tracked multiple measures, such as age, duration of diabetes, reason for pump placement, HbA1c, severe hypoglycemic events and DKA, insulin dosage, growth parameters, and validated measures of knowledge, adherence, responsibility, integration, and quality of life.

    In 1999, 83 patients had been on insulin pump therapy in our center for a mean of 2.2 years. The mean age of subjects was 13.6 ± 3.9 years, with a mean diabetes duration of 5.3 ± 3.2 years. Of these, 55% were placed on CSII because they desired optimal basal/bolus management, 30% were given insulin pumps to improve glycemic control, 7% were placed on pumps to ameliorate severe hypoglycemia, and 8% started pump therapy because of recurrent DKA.9,10

    Table 3 shows the pre- and post-pump HbA1c, body mass index (BMI), and hypoglycemia and DKA rates in our overall cohort as well as results on the validated measures listed above. As shown, there were significant improvements in all measures and no change in BMI. Included in our patient population at this time were six children ≤7 years of age.

    Because of this overall success, by the end of 2000, our pump population had increased to 210 subjects (14% of our type 1 diabetic subjects), and we had pre- and post-pump data of at least 6 months’ duration on 11 subjects ≤7 years. These data are shown in Table 4. They show a decrease in HbA1c and mean blood glucose levels. The smaller standard deviation of the mean blood glucose level indicates that there was less glycemic excursion with the pump. These lower mean blood glucose and HbA1c values were obtained at the same time there was a reduction in the severe hypoglycemia rate.

    In addition, there were no episodes of DKA. The risk of DKA had been a potential concern because without a depot of intermediate- or long-acting insulin, it was believed that if the pump catheter dislodged or the pump malfunctioned, DKA would rapidly ensue. However, this did not occur in our patients.

    Results of scores on validated measures from the Child Health Questionnaire13 revealed that the impact that diabetes had on family functioning, family activity, and family cohesion was significantly improved with CSII.

    Six young subjects were placed on CSII to optimize basal/bolus therapy, three because of recurrent hypoglycemia, and two to improve glycemic control. The number of pump basal rates was less in young children compared with the older cohort of pump patients in our center (2.9 ± 2.1 for children ≤7 of age vs. 4.1 ± 1.8 for children 8–13 years, P = 0.05). There was no difference in the insulin dosage between the young cohort and older subjects (0.55 ± 0.13 U/kg/day vs. 0.62 ± 0.17 U/kg/day, P = NS).

    Over the past 8 years, ∼10% of the patients we started on CSII have gone back to injection therapy. This has been because of inability to wear the pump, failure to comply with the regimen, or lack of family support. All subjects who have discontinued have been teens; none were young children.

    Because the pump is a health care expense, we were concerned that pumps would be more easily lost or damaged by young children who developmentally lack the ability to care for possessions. This has not been the case. Overall, very few pump accidents have occurred, and there has been no difference in the low rate of pump damage or loss (<5%/year) among age-groups (young children, school-aged children, and teens).

    Use of the Pump at Night for Young Children

    Although we have found CSII to be of benefit in young preschool and school-aged children, we have questioned the developmental capability of some children 7–10 years of age to manage the pump 24 h/day. These children are away from their parents and must assume some responsibility for pump management, in contradistinction to younger children who cannot be expected to perform any of the tasks required to manage CSII.

    In these children 7–10 years of age, we evaluated the efficacy of insulin pump treatment only at night.14 This concept had originally been put forth by Schiffrin and Belmonte15 and Kanc et al.16 in an older cohort of children who had reduced HbA1c levels, less hypoglycemia, and more normal fasting blood glucose levels with night insulin pump treatment. In our study of 10 children 7–10 years of age, nighttime CSII appeared to be beneficial.14

    Our study cohort had on entry a mean diabetes duration of 3.4 ± 1.6 years and a mean HbA1c of 7.6 ± 0.9% and took a mean of 0.9 ± 0.3 U of insulin/kg/day. Our study entailed a crossover design between three injections/day and CSII at night.

    The results showed that, compared with baseline levels, the use of the pump resulted in a significant decrease in the mean average blood glucose (186 ± 31.9 vs. 160 ± 19.6 mg/dl, P = 0.001), breakfast (197 ± 31.2 vs. 125 ± 31.3 mg/dl, P = 0.0001), and 3:00 a.m. (173 ± 48.8 vs. 132 ± 25.2 mg/dl, P = 0.003) blood glucose levels. In addition, there was a decrease in the percentage of blood glucose levels less than the target range (21 ± 10.0% vs. 15 ± 6.3%, P = 0.01), a decrease in fructosamine values (386 ± 56 vs. 345 ± 36.6 μmol/l, P = 0.01), and an increase in the percentage of blood glucose values within the target range (36 ± 7.5% vs. 44 ± 6.7%, P = 0.03). There were no adverse events during the pump portion of the study. Specifically, there were no episodes of severe hypoglycemia.

    This study indicates that nighttime-only insulin pump therapy can be used to improve glycemia in young children who cannot be managed 24 h/day with CSII because they lack the developmental/cognitive skills to be independent when they are not cared for by their parents or other adults competent in pump management.

    Insulin Pump Therapy Coupled With the Continuous Glucose Monitoring System

    We have recently used the continuous glucose monitoring system (CGMS) (MiniMed, Sylmar, CA) to evaluate the efficacy of pump therapy in our patient population (F.R.K., L.C. Gibson, M.H., S.C., L.K. Fisher, P.P., unpublished data). CGMS measures subcutaneous interstitial glucose levels continuously, recording values on average every 5 min within a range of 40–400 mg/dl.17 Because the CGMS is a light-weight, portable, minimally invasive system, it was possible to employ this in our pediatric patients, including young children.

    We compared the glycemic patterns over a mean of 4.3 ± 1.4 days in 24 children on three to four injections per day with that of 23 children on CSII. There were more abnormal glucose patterns (defined as >50% of glucose values outside the target range during any of the nine time periods/day—three premeal, three postmeal, and three night periods [bedtime to midnight, midnight to 3:00 a.m., and 3:00 a.m. to waking]) with injection therapy compared with the pump (130 abnormal glucose patterns in the injection group compared with 80 abnormal patterns in the pump group).

    Figure 1 shows an example of an abnormally high glucose pattern after breakfast in a 4-year-old patient on CSII. Figure 2 shows a tracing from a 6-year-old pump patient without an abnormal glucose value.

    We have found that the information from CGMS can be used to alter insulin regimens, particularly the bolus insulin therapy, for pump patients. This has led to a decrease in HbA1c in patients selected because of glucose management problems.17 We are in the process of evaluating the efficacy of obtaining CGMS on all CSII patients 2–3 months after starting on the pump. We hypothesize that this will improve our ability to regulate glycemia by ensuring that basal, bolus, and correction doses are optimal.

    Conclusions

    Our experience with insulin pump therapy in young children, as well as our entire population on CSII, has been extremely positive. Our young patients have had a reduction in HbA1c, mean blood glucose levels, and glycemic excursion; a decrease in episodes of severe hypoglycemia; and an increase in family functioning around diabetes.

    We believe the success of our pump program in young children can be attributed to the fact that we have employed appropriate criteria for patient selection and have a standardized method to initiate pump therapy and to follow and support our patients/families. Our center has a sufficient number of experienced diabetes educators to be able to take daily phone calls and to perform ongoing teaching/validation over the weeks to months required to achieve stable glycemia. Our Insulin Dosage Guide, modification of the pump manual, use of CSII at nighttime only, and use of CGMS to evaluate glycemia and modify insulin dosages all have enabled us to maximize the benefit of CSII in young children with no apparent negative medical or lifestyle consequences.

    To date, there have not been many reports to support advocating the use of CSII in young children. The recent Consensus Guidelines 2000 of the International Society for Pediatric and Adolescent Diabetes18 advocated the use of external insulin pumps in young children. These guidelines stated that pumps have been proven successful in young infants in need of diabetes stabilization. However, there were no specific references given to support this statement.

    This relative dearth of specific evidence supporting the efficacy of pump use in young children has led many pediatric endocrinologists to avoid CSII in children <6 years of age. To rigorously determine the role of CSII in this age-group, randomized trials should be conducted.

    These should include cost/benefit analyses because pump therapy adds short-term cost to the economic burden of diabetes. However, there is evidence that the improvement in glycemic control appreciated with CSII may reduce the long-term cost of caring for patients with this devastating disease.3

    At present, the results of our experience would suggest that CSII can be used with success in young children. Specifically, pump therapy should not be avoided in young children who meet one of the four medical indications; who have motivated parents with the appropriate knowledge, skills, and attitude; and who are cared for by a diabetes team expert in pump therapy. With no data to the contrary, CSII should be considered a viable diabetes management alternative in children of any age.

    Figure 1
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    Figure 1

    CGMS Tracing of a 4 year old with a high post-breakfast pattern.

    Figure 2
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    Figure 2

    CGMS tracing of a 6-year-old with no abnormal glucose patterns.

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    Table 1.

    Standard Criteria for Pump Selection

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    Table 2.

    Competency Level Scale, from 1–8, Used in Our Center to Determine Appropriateness of CSII (For CSII, Level 5)

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    Table 3.

    1999 Data on CSII for Pediatric Subjects at Childrens Hospital Los Angeles

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    Table 4.

    Data on Patients ≤7 Years of Age Using CSII

    Footnotes

    • Francine Ratner Kaufman, MD, is a professor of pediatrics at the Keck School of Medicine at the University of Southern California in Los Angeles and head of the Division of Endocrinology & Metabolism at Childrens Hospital Los Angeles. Mary Halvorson, RN, MNS, CDE, is the administrator, and Sue Carpenter, RN, CDE, is a case manager in the Division of Endocrinology & Metabolism at Childrens Hospital Los Angeles. Debra Devoe, MD, and Pisit Pitukcheewanont, MD, are associate professors of pediatrics at the Keck School of Medicine at the University of Southern California in Los Angeles and the Division of Endocrinology & Metabolism at Childrens Hospital Los Angeles.

    • Note of disclosure: Dr. Kaufman is a stock shareholder in MiniMed, Inc., which manufactures insulin pumps and the Continuous Glucose Monitoring System. She has served as an advisor or speaker’s bureau member and has received research support from MiniMed, as well as Novo Nordisk and Eli Lilly, both of which manufacture insulin. Ms. Halvorson is a stock shareholder in MiniMed, Inc., and has received honoraria and research support from MiniMed, Eli Lilly, and Novo Nordisk. Ms. Carpenter is a stock shareholder in MiniMed, Inc.

    • American Diabetes Association

    References

    1. ↵
      Saudek CD: Novel forms of insulin delivery. Endocrinol Metab Clin North Am 26:599–610, 1997
      OpenUrlCrossRefPubMedWeb of Science
    2. ↵
      Hirsch IB: Intensive treatment of type 1 diabetes. Med Clin North Am 82:689–720, 1998
      OpenUrlCrossRefPubMedWeb of Science
    3. ↵
      The DCCT Research Group: The effect of intensive diabetes treatment on the development and progression of long-term complications of insulin-dependent diabetes mellitus. N Engl J Med 329:977–986, 1993
      OpenUrlCrossRefPubMedWeb of Science
    4. ↵
      Tamborlane WV, Sherwin RS, Genel M, Felig P: Reduction to normal plasma glucose in juvenile diabetes by subcutaneous administration of insulin with a portable infusion pump. N Engl J Med 300:573–578, 1979
      OpenUrlCrossRefPubMedWeb of Science
    5. ↵
      Tamborlane WV, Sherwin RS, Genel M, Felig P: Outpatient treatment of juvenile-onset diabetes with a preprogrammed portable subcutaneous insulin infusion system. Am J Med 22:175–179, 1980
      OpenUrl
    6. ↵
      Farkas-Hirsch R, Hirsch IB: Continuous subcutaneous insulin infusion: a review of the past and its implementation for the future. Diabetes Spectrum 7:80–84, 1994
      OpenUrl
    7. ↵
      Rudolf MCJ, Sherwin RS, Markowitz R, Bates SE, Genel M, Hochstadt J, Tamborlane WV: Effect of intensive insulin treatment on linear growth in the young diabetic patient. J Pediatr 1010:37–39, 1983
      OpenUrl
    8. ↵
      Steindel BS, Roe TR, Costin G, Carlson M, Kaufman FR: Continuous subcutaneous insulin infusion (CSII) in children and adolescents with chronic poorly controlled type 1 diabetes mellitus. Diabetes Res Clin Pract 27:199–204, 1995
      OpenUrlCrossRefPubMedWeb of Science
    9. ↵
      Kaufman FR, Halvorson M, Miller D, Mackensie, M, Fisher LK, Pitukcheewanont P: Insulin pump therapy in type 1 pediatric patients: now and into the year 2000. Diabetes Metab Res Rev 15:338–352, 1999
      OpenUrlCrossRefPubMedWeb of Science
    10. ↵
      Kaufman FR, Halvorson M, Fisher L, Pitukcheewanont P: Insulin pump therapy in type 1 pediatric patients. J Pediatr Endocrinol Metab 12:759–764, 1999
    11. ↵
      Bode BW: Pumping protocol: a physician guide to insulin pump therapy initiation. Supported by an educational grant from MiniMed, 1997
    12. ↵
      Kaufman FR, Halvorson M, Carpenter S: Use of a plastic insulin dosage guide to correct blood glucose levels out of the target range and for carbohydrate counting in children with type 1 diabetes. Diabetes Care 22:1252–1257, 1999
      OpenUrlAbstract
    13. ↵
      Landgraf JM, Abbott L, Ware J: Child Health Questionnaire. In DHQ:C Users Manual. Boston, The Health Institute, New England Medical Center, 1996
    14. ↵
      Kaufman FR, Halvorson M, Kim C, Pitukcheewanont P: Use of insulin pump therapy at nighttime only for children 7–10 years of age with type 1 diabetes. Diabetes Care 23:579–582, 2000
      OpenUrlAbstract/FREE Full Text
    15. ↵
      Schiffrin A, Belmonte M: Combined continuous subcutaneous insulin infusion and multiple subcutaneous injections in type 1 diabetic patients. Diabetes Care 4:595–600, 1981
      OpenUrlAbstract/FREE Full Text
    16. ↵
      Kanc K, Janssen MMJ, Keulen ET, Jacobs MA, Popp-Snijders C, Snoek FJ: Substitution of night-time continuous subcutaneous insulin infusion therapy for bedtime NPH insulin in a multiple injection regimen improves counterregulatory hormonal responses and warning symptoms of hypoglycemia in IDDM. Diabetologia 41:322–329, 1998
      OpenUrlCrossRefPubMedWeb of Science
    17. ↵
      Mostrototoro JJ: The MiniMed continuous glucose monitoring system (CGMS). J Pediatr Endocrinol Metab 12 (Suppl. 3):751–758, 1999
    18. ↵
      International Society for Pediatric and Adolescent Diabetes: Consensus Guidelines 2000. Zeist, Netherlands, Medical Forum International, 2000
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    Pump Therapy for Children: Weighing the Risks and Benefits
    Francine Ratner Kaufman, Mary Halvorson, Sue Carpenter, Debra Devoe, Pisit Pitukcheewanont
    Diabetes Spectrum Apr 2001, 14 (2) 84-89; DOI: 10.2337/diaspect.14.2.84

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    Pump Therapy for Children: Weighing the Risks and Benefits
    Francine Ratner Kaufman, Mary Halvorson, Sue Carpenter, Debra Devoe, Pisit Pitukcheewanont
    Diabetes Spectrum Apr 2001, 14 (2) 84-89; DOI: 10.2337/diaspect.14.2.84
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    • Article
      • Abstract
      • Patient Selection
      • Advantages and Disadvantages of CSII in Young Children
      • Methods for Pump Initiation
      • Longitudinal Results of CSII Experience at Childrens Hospital Los Angeles
      • Use of the Pump at Night for Young Children
      • Insulin Pump Therapy Coupled With the Continuous Glucose Monitoring System
      • Conclusions
      • Footnotes
      • References
    • Figures & Tables
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