RT Journal Article
SR Electronic
T1 The Pathophysiology of Cardiovascular Disease and Diabetes: Beyond Blood Pressure and Lipids
JF Diabetes Spectrum
FD American Diabetes Association
SP 160
OP 165
DO 10.2337/diaspect.21.3.160
VO 21
IS 3
A1 Dokken, Betsy B.
YR 2008
UL http://spectrum.diabetesjournals.org/content/21/3/160.abstract
AB In BriefThe pathophysiology of the link between diabetes and cardiovascular disease (CVD) is complex and multifactorial. Understanding these profound mechanisms of disease can help clinicians identify and treat CVD in patients with diabetes, as well as help patients prevent these potentially devastating complications. This article reviews the biological basis of the link between diabetes and CVD, from defects in the vasculature to the cellular and molecular mechanisms specific to insulin-resistant states and hyperglycemia. It concludes with a discussion of heart failure in diabetes, a clinical entity that demonstrates many of the mechanisms discussed.