TABLE 1.

Characteristics of Type 1 Diabetes, Type 2 Diabetes, and LADA

Type 1 DiabetesType 2 DiabetesLADA
Age (years)<35>35≥30
C-peptideVery lowNormal to highLow
ICAOften positiveNegativeCan be positive
GAD65Often positiveNegativeCan be positive
IA-2Often positiveNegativeCan be positive
IAAOften positiveNegativeCan be positive
Circulating insulinRapidly deficientExcessive and resistantGradually deficient
Time to requiring insulinAt onsetCan be many yearsWithin 6 months (variable)