TABLE 1.

Titration Algorithms Evaluated in Clinical Trials

TrialStudy GroupComparison Group
Treat-to-target (50)Algorithm 1: Gla-100 titrationAlgorithm 2: NPH titration
Increase Gla-100 dose by:Increase NPH dose by:
• 8 units with FPG ≥180 mg/dL• 8 units with FPG ≥180 mg/dL
• 6 units with FPG 140–180 mg/dL• 6 units with FPG 140–180 mg/dL
• 4 units with FPG 120–140 mg/dL• 4 units with FPG 120–140 mg/dL
• 2 units with FPG ≥100–120 mg/dL• 2 units with FPG ≥100–120 mg/dL
ATLANTUS study (43)Algorithm 1: Patient self-titrationAlgorithm 2: Physician titration
Increase Gla-100 dose by:Increase Gla-100 dose by:
• 6–8 units with FPG ≥180 mg/dL• 2 units with FPG ≥180 mg/dL
• 4 units with FPG 140–180 mg/dL• 2 units with FPG 140–180 mg/dL
• 2 units with FPG 120–140 mg/dL• 2 units with FPG 120–140 mg/dL
• 0–2 units with FPG ≥100–120 mg/dL• 0–2 units with FPG ≥100–120 mg/dL
PREDICTIVE study (44)Patient self-titrationStandard care
• Decrease insulin detemir by 3 units with mean FPG <80 mg/dL
• Keep insulin detemir dose the same with mean FPG 80–100 mg/dL
• Increase insulin detemir dose by 3 units with FPG >110 mg/dL
INSIGHT trial (45)Patient self-titrationEDITION algorithm
• Increase Gla-300 dose by 1 unit/day if FPG >100 mg/dL• Increase Gla-300 dose by:
 3 units if SMPG value >100 and <140 mg/dL
 6 units if SMPG value ≥140 mg/dL
• Decrease by 3 units if SMPG value <79 mg/dL
  • SMPG, self-monitoring of plasma glucose.