TABLE 5

Analysis of Adjusted CGM Variables Tested for Associations With LGA Status

VariableLGA (n = 98)No LGA (n = 88)Adjusted OR (95% CI)P
First trimester
A1C, mmol/mol54.1 ± 1.050.4 ± 9.51.04 (1.00–1.08)0.02*
A1C, %7.1 ± 1.06.8 ± 0.9
Mean glucose, mmol/L7.9 ± 1.37.7 ± 1.51.16 (0.19–1.49)0.24
SD, mmol/L3.2 ± 0.83.2 ± 0.91.09 (0.73–1.62)0.67
Coefficient of variation, %40.5 ± 7.240.6 ± 7.30.99 (0.95–1.04)0.77
TIR, %48.2 ± 13.651.9 ± 14.50.98 (0.95–1.00)0.07
TAR, %44.8 ± 14.640.9 ± 16.31.02 (1.00–1.04)0.07
TBR, %7.0 ± 5.17.2 ± 5.00.98 (0.92–1.05)0.60
Second trimester
A1C, mmol/mol46.4 ± 7.443.7 ± 8.31.05 (1.01–1.10)0.02*
A1C, %6.4 ± 0.76.1 ± 0.8
Mean glucose, mmol/L7.6 ± 1.07.1 ± 1.31.53 (1.12–2.08)<0.001*
SD, mmol/L2.9 ± 0.62.7 ± 0.71.65 (1.00–2.74)<0.05*
Coefficient of variation, %37.8 ± 5.937.7 ± 6.71.00 (0.95–1.06)0.93
TIR, %51.8 ± 12.357.9 ± 14.40.96 (0.94–0.99)<0.01*
TAR, %41.9 ± 12.834.0 ± 15.91.04 (1.02–1.07)<0.001*
TBR, %6.4 ± 4.58.0 ± 5.70.93 (0.87–0.99)0.02*
Third trimester
A1C, mmol/mol47.2 ± 6.744.0 ± 8.21.06 (1.02–1.11)<0.01*
A1C, %6.5 ± 0.66.2 ± 0.8
Mean glucose, mmol/L7.3 ± 1.16.8 ± 1.11.57 (1.12–2.19)<0.001*
SD, mmol/L2.6 ± 0.62.5 ± 0.61.60 (0.92–2.77)0.09
Coefficient of variation, %35.9 ± 5.536.1 ± 6.20.99 (0.94–1.05)0.84
TIR, %57.6 ± 12.862.2 ± 13.40.97 (0.95–1.00)0.04*
TAR, %37.0 ± 13.530.2 ± 15.31.03 (1.01–1.06)<0.01*
TBR, %5.4 ± 4.47.6 ± 6.40.92 (0.86–0.98)<0.01*
  • Adjusted for age, smoking status, BMI, and CGM device. Data in LGA and non-LGA columns are mean ± SD.

  • * Statistically significant.

  • TIR 63–140 mg/dL (3.5–7.8 mmol/L). Adapted from ref. 2.